RT Book, Section
A1 Killu, Claude
A1 J. Ault, Mark
A2 McKean, Sylvia C.
A2 Ross, John J.
A2 Dressler, Daniel D.
A2 Scheurer, Danielle B.
SR Print(0)
ID 1137613138
T1 Lumbar Puncture
T2 Principles and Practice of Hospital Medicine, 2e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071843133
LK accessmedicine.mhmedical.com/content.aspx?aid=1137613138
RD 2024/04/19
AB Lumbar  puncture  (LP)  is  performed  to  sample  the  cerebrospinal  fluid  (CSF)  surrounding  the  brain  and  spinal  cord.  The  majority  of  the  CSF  is  in  the  subarachnoid  space,  where  the  arachnoid  membranes  bridge  the  sulci  of  the  brain,  in  the  basal  cisterns  and  around  the  spinal  cord.  Cerebrospinal  fluid  moves  within  the  ventricles  and  subarachnoid  spaces  under  the  influence  of  hydrostatic  pressure  generated  by  the  production  of  CSF  by  the  choroid  plexus  of  the  lateral  third  and  fourth  ventricles.  The  volume  of  CSF  in  humans  is  140  to  150  mL  of  which  only  30  to  40  mL  is  actually  in  the  ventricular  system,  with  a  production  rate  of  21  mL/h.  The  turnover  rate  of  total  CSF  is  about  5  hours  for  an  average  sized  human.  Cerebrospinal  fluid  cushions  the  brain,  regulates  brain  extracellular  fluid,  allows  for  distribution  of  neuroactive  substances,  and  collects  the  waste  products  produced  by  the  brain.