RT Book, Section A1 Penaco, Annie Lynn A1 Berger, Jay A2 Oropello, John M. A2 Pastores, Stephen M. A2 Kvetan, Vladimir SR Print(0) ID 1136418122 T1 Controversies: Patient-Controlled Sedation—Ready for Prime Time? T2 Critical Care YR 1 FD 1 PB McGraw-Hill Education PP New York, NY SN 9780071820813 LK accessmedicine.mhmedical.com/content.aspx?aid=1136418122 RD 2024/03/29 AB KEY POINTSDepth of sedation exists as a continuum from minimal sedation where the patient is able to interact during the sedation to deep sedation which is just short of general anesthesia.Patient-controlled sedation is an extension of patient-controlled analgesia, where the patient is able to control the depth of sedation that is comfortable for them during an invasive procedure.Primary focus on the use of patient-controlled sedation is in the setting of ambulatory procedures that are typically performed under local or regional anesthesia.The highly titratable nature of sedation requires the use of medications that are highly potent with rapid onsets of action.The use of target-controlled infusion allows for more stable plasma concentrations of the sedative medication during the procedure.Patient-maintained sedation utilizing target-controlled infusions is produces more stable plasma concentrations; however, the time to reach adequate sedation is relatively slower as compared to patient-controlled sedation.Most common adverse event encountered during sedation is respiratory depression, manifested as hypoxemia and decreased respiratory rate.