RT Book, Section A1 McCarthy, Jeanette J. A1 Mendelsohn, Bryce A. SR Print(0) ID 1134735739 T1 Wellness T2 Precision Medicine: A Guide to Genomics in Clinical Practice YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9781259644139 LK accessmedicine.mhmedical.com/content.aspx?aid=1134735739 RD 2024/03/29 AB Over a million people have taken advantage of direct-to-consumer genetic testing, mostly through the genetic testing company 23andMe. Some are motivated by the desire to know their ancestry, while others hope to gain insight into their disease risks. We are also seeing the launch of dozens of local and international projects that will generate, and hopefully return results of the genome sequences of millions of people. These include efforts by the U.S. Precision Medicine Initiative Cohort, Human Longevity, Inc., the Million Vets Program, Genome England's 100K Genome Project, the Saudi Human Genome Program, and others[1]. It is expected that genome sequencing will become a part of routine health care in the not too distant future. Most of this sequencing will be done on ostensibly healthy individuals. Health care providers need to be aware of the value and limitations of genome sequencing, as they will likely encounter a patient who has this information in hand and asks them what it means. This chapter will help prepare health care providers for a healthy patient coming to them with their genomic information.