RT Book, Section
A1 McCarthy, Jeanette J.
A1 Mendelsohn, Bryce A.
SR Print(0)
ID 1134735479
T1 Cancer Predisposition Testing
T2 Precision Medicine: A Guide to Genomics in Clinical Practice
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9781259644139
LK accessmedicine.mhmedical.com/content.aspx?aid=1134735479
RD 2024/04/19
AB The  availability  and  general  awareness  of  hereditary  cancer  predisposition  tests  has  grown  substantially  in  the  past  several  years,  owing  in  part  to  the  continued  discovery  of  cancer  susceptibility  genes,  the  reversal  of  gene  patent  laws[1],  and  high-profile  celebrity  cases[2].  The  result  is  that  numerous  laboratories  now  offer  genetic  tests  for  inherited  breast,  colorectal,  and  other  cancers.  The  types  of  tests  offered  is  changing  as  well,  due  to  the  introduction  of  next-generation  sequencing  technologies,  which  allow  for  faster  and  cheaper  analysis  of  genetic  variation.  The  field  is  moving  away  from  testing  single  genes  and  toward  testing  panels  of  genes.  Recently,  we  have  seen  a  nearly  10-fold  drop  in  the  cost  of  genetic  testing[3].  Patients  with  a  personal  or  family  history  of  cancer  may  be  candidates  for  inherited  cancer  predisposition  testing,  and  in  time  with  fewer  barriers  to  access,  screening  for  cancer  risk  may  spread  to  the  general  population.