RT Book, Section
A1 McCarthy, Jeanette J.
A1 Mendelsohn, Bryce A.
SR Print(0)
ID 1134734933
T1 Family History
T2 Precision Medicine: A Guide to Genomics in Clinical Practice
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9781259644139
LK accessmedicine.mhmedical.com/content.aspx?aid=1134734933
RD 2024/04/25
AB Family  history  is  a  risk  factor  for  many  common  diseases,  capturing  both  shared  genetic  variation  and  shared  environment  between  family  members.  Because  our  understanding  of  genetic  risk  factors  for  common  diseases  is  incomplete,  family  history  remains  an  important  component  of  any  medical  assessment.  A  family  history  of  a  common  disease  is  usually  associated  with  a  two  to  threefold  increased  risk  of  disease  in  bloodline  family  relatives.  To  put  this  in  context,  this  risk  is  much  higher  than  for  most  known  individual  genetic  variants  for  common  diseases  (average  increased  risk  for  variants  discovered  to  date  are  about  1.18-fold).