RT Book, Section A1 McCarthy, Jeanette J. A1 Mendelsohn, Bryce A. SR Print(0) ID 1134734583 T1 The Human Genome and Genetic Variation T2 Precision Medicine: A Guide to Genomics in Clinical Practice YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9781259644139 LK accessmedicine.mhmedical.com/content.aspx?aid=1134734583 RD 2024/03/28 AB The Human Genome Project has taught us a great deal about the different types of variations that exist in our genomes and their distribution across human populations. Humans are 99.9% identical at the DNA level, but the corollary is that at 0.1% of the nucleotide positions, translating to about 4–5 million basepairs on average, we differ[1]. These genetic differences will vary in their effect on human traits according to their location with respect to genes and their impact on the downstream proteins that those genes encode.