RT Book, Section
A1 Kasper, Dennis L.
A1 Fauci, Anthony S.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Jameson, J. Larry
A1 Loscalzo, Joseph
SR Print(0)
ID 1128787473
T1 Osteoarthritis
T2 Harrison's Manual of Medicine, 19e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071828529
LK accessmedicine.mhmedical.com/content.aspx?aid=1128787473
RD 2024/04/20
AB Osteoarthritis  (OA)  is  a  disorder  characterized  by  progressive  joint  failure  in  which  all  structures  of  the  joint  have  undergone  pathologic  change.  The  pathologic  sine  qua  non  of  OA  is  hyaline  articular  cartilage  loss  accompanied  by  increasing  thickness  and  sclerosis  of  the  subchondral  bone  plate,  outgrowth  of  osteophytes  at  the  joint  margin,  stretching  of  the  articular  capsule,  and  weakness  of  the  muscles  bridging  the  joint.  There  are  numerous  pathways  that  lead  to  OA,  but  the  initial  step  is  often  joint  injury  in  the  setting  of  a  failure  of  protective  mechanisms.