RT Book, Section
A1 Kasper, Dennis L.
A1 Fauci, Anthony S.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Jameson, J. Larry
A1 Loscalzo, Joseph
SR Print(0)
ID 1128786633
T1 Renal Transplantation
T2 Harrison's Manual of Medicine, 19e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071828529
LK accessmedicine.mhmedical.com/content.aspx?aid=1128786633
RD 2024/04/25
AB With  the  advent  of  more  potent  and  well-tolerated  immunosuppressive  regimens  and  further  improvements  in  short-term  graft  survival,  renal  transplantation  remains  the  treatment  of  choice  for  most  pts  with  end-stage  renal  disease.  Results  are  best  with  living-related  transplantation,  in  part  because  of  optimized  tissue  matching  and  in  part  because  waiting  time  and  ischemic  time  can  be  minimized;  ideally,  these  pts  are  transplanted  prior  to  the  onset  of  symptomatic  uremia  or  indications  for  dialysis.  Transplant  centers  now  also  perform  living-unrelated  donor  (e.g.,  spousal)  transplants,  often  in  “chains”  involving  multiple  donors  to  optimize  tissue  matching.  Graft  survival  in  these  cases  is  far  superior  to  that  observed  with  deceased  donor  transplants,  although  less  favorable  than  with  living-related  transplants.