RT Book, Section
A1 Kasper, Dennis L.
A1 Fauci, Anthony S.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Jameson, J. Larry
A1 Loscalzo, Joseph
SR Print(0)
ID 1128786488
T1 Pulmonary Thromboembolism and Deep-Vein Thrombosis
T2 Harrison's Manual of Medicine, 19e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071828529
LK accessmedicine.mhmedical.com/content.aspx?aid=1128786488
RD 2024/04/24
AB Venous  thromboembolism  includes  both  deep-vein  thrombosis  (DVT)  and  pulmonary  thromboembolism  (PE).  DVT  results  from  blood  clot  formation  within  large  veins,  usually  in  the  legs.  PE  results  from  DVTs  that  have  broken  off  and  traveled  to  the  pulmonary  arterial  circulation.  Isolated  calf  vein  thrombi  have  much  lower  risk  of  PE.  Although  DVTs  are  typically  related  to  thrombus  formation  in  the  legs  and/or  pelvis,  indwelling  venous  catheters,  pacemakers,  and  internal  cardiac  defibrillators  have  increased  the  occurrence  of  upper  extremity  DVT.  In  the  absence  of  PE,  the  major  complication  of  DVT  is  postthrombotic  syndrome,  which  causes  chronic  leg  swelling  and  discomfort  due  to  damage  to  the  venous  valves  of  the  affected  leg.  In  its  most  severe  form,  postthrombotic  syndrome  causes  skin  ulceration.  PE  is  often  fatal,  usually  due  to  progressive  right  ventricular  failure.  Chronic  thromboembolic  pulmonary  hypertension  is  another  long-term  complication  of  PE.