RT Book, Section
A1 Kasper, Dennis L.
A1 Fauci, Anthony S.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Jameson, J. Larry
A1 Loscalzo, Joseph
SR Print(0)
ID 1128785212
T1 HIV Infection and AIDS
T2 Harrison's Manual of Medicine, 19e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071828529
LK accessmedicine.mhmedical.com/content.aspx?aid=1128785212
RD 2024/04/24
AB AIDS  was  originally  defined  empirically  by  the  Centers  for  Disease  Control  and  Prevention  (CDC)  as  “the  presence  of  a  reliably  diagnosed  disease  that  is  at  least  moderately  indicative  of  an  underlying  defect  in  cell-mediated  immunity  in  the  absence  of  any  known  cause  for  such  a  defect.”  Following  the  recognition  of  the  causative  virus,  HIV,  and  the  development  of  sensitive  and  specific  tests  for  HIV  infection,  the  definition  of  AIDS  has  undergone  substantial  revision.  The  current  surveillance  definition  categorizes  HIV-infected  persons  on  the  basis  of  clinical  conditions  associated  with  HIV  infection  and  CD4+  T  lymphocyte  counts  (Tables  226-1,  and  226-2,  pp.  1215  and  1216,  in  HPIM-19).  From  a  practical  standpoint,  the  clinician  should  view  HIV  disease  as  a  spectrum  of  disorders  ranging  from  primary  infection,  with  or  without  the  acute  HIV  syndrome,  to  the  asymptomatic  infected  state,  to  advanced  disease  characterized  by  opportunisitic  infections  and  neoplasms.