RT Book, Section
A1 Kasper, Dennis L.
A1 Fauci, Anthony S.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Jameson, J. Larry
A1 Loscalzo, Joseph
SR Print(0)
ID 1128783708
T1 Cancer of Unknown Primary Site
T2 Harrison's Manual of Medicine, 19e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071828529
LK accessmedicine.mhmedical.com/content.aspx?aid=1128783708
RD 2024/04/19
AB Cancer  of  unknown  primary  site  (CUPS)  is  defined  as  follows:  biopsy-proven  malignancy;  primary  site  unapparent  after  history,  physical  examination,  chest  x-ray,  abdominal  and  pelvic  CT,  complete  blood  count,  chemistry  survey,  mammography  (women),  β-human  chorionic  gonadotropin  (hCG)  levels  (men),  α-fetoprotein  (AFP)  levels  (men),  and  prostate-specific  antigen  (PSA)  levels  (men);  and  histologic  evaluation  not  consistent  with  a  primary  tumor  at  the  biopsy  site.  CUPS  incidence  is  declining,  probably  because  of  better  pathology  diagnostic  criteria;  it  accounts  for  about  3%  of  all  cancers  today,  down  from  10–15%  15  years  ago.  Most  pts  are  over  age  60.  The  tumors  are  often  aneuploid.  Cell  lines  derived  from  such  tumors  frequently  have  abnormalities  in  chromosome  1.