RT Book, Section
A1 Kasper, Dennis L.
A1 Fauci, Anthony S.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Jameson, J. Larry
A1 Loscalzo, Joseph
SR Print(0)
ID 1128782189
T1 Anaphylaxis
T2 Harrison's Manual of Medicine, 19e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071828529
LK accessmedicine.mhmedical.com/content.aspx?aid=1128782189
RD 2024/04/16
AB A  life-threatening  systemic  hypersensitivity  reaction  to  contact  with  an  allergen;  it  may  appear  within  minutes  of  exposure  to  the  offending  substance.  Manifestations  include  respiratory  distress,  pruritus,  urticaria,  mucous  membrane  swelling,  GI  disturbances  (including  nausea,  vomiting,  abdominal  pain,  and  diarrhea),  and  vascular  collapse.  Virtually  any  allergen  may  trigger  an  anaphylactic  reaction,  but  among  the  more  common  agents  are  proteins  such  as  antisera,  hormones,  pollen  extracts,  Hymenoptera  venom,  and  foods;  drugs  (especially  antibiotics);  and  diagnostic  agents  such  as  IV  contrast  material.  Atopy  does  not  seem  to  predispose  to  anaphylaxis  from  penicillin  or  venom  exposures.  Anaphylactic  transfusion  reactions  are  covered  in  Chap.  8.