RT Book, Section A1 Tsimberidou, Apostolia-Maria A2 Kantarjian, Hagop M. A2 Wolff, Robert A. SR Print(0) ID 1126745887 T1 Targeted Therapy in Cancer T2 The MD Anderson Manual of Medical Oncology, 3e YR 2016 FD 2016 PB McGraw-Hill Medical PP New York, NY SN 9780071847940 LK accessmedicine.mhmedical.com/content.aspx?aid=1126745887 RD 2024/03/29 AB The Human Genome Project has enabled sequencing of human DNA and led to advancements in technologies that detect genomic, transcriptional, proteomic, and epigenetic changes. These technologies, combined with novel drug development, have accelerated the implementation of personalized medicine. Personalized medicine uses concepts of the genetic and environmental bases of disease to individualize prevention, diagnosis, and treatment (1,2). Optimization of treatment using targeted therapy—molecules targeting specific enzymes, growth factor receptors, and signal transducers, thereby interfering with a variety of oncogenic cellular processes—and other strategies made possible by advances in translational medicine holds the promise of improving patient care (3).