RT Book, Section
A1 Overman, Michael J.
A1 Raghav, Kanwal
A1 Lieu, Christopher H.
A1 Fournier, Commentary: Keith F.
A2 Kantarjian, Hagop M.
A2 Wolff, Robert A.
SR Print(0)
ID 1126742442
T1 Small Bowel Cancer and Appendiceal Tumors
T2 The MD Anderson Manual of Medical Oncology, 3e
YR 2016
FD 2016
PB McGraw-Hill Medical
PP New York, NY
SN 9780071847940
LK accessmedicine.mhmedical.com/content.aspx?aid=1126742442
RD 2024/04/19
AB Small  bowel  cancer  is  a  rare  malignancy  representing  approximately  3%  of  gastrointestinal  neoplasms  (1).  In  2014,  it  was  estimated  that  9,160  new  cases  of  small  bowel  cancer  and  1,210  small  bowel  cancer–related  deaths  would  occur  (1).  The  two  most  common  histologies  seen  in  cancers  of  the  small  intestine  are  carcinoids  and  adenocarcinomas  (2).  Because  of  the  nonspecific  clinical  presentation  of  small  bowel  adenocarcinoma  and  the  difficulty  in  imaging  the  small  bowel,  most  patients  with  small  bowel  adenocarcinoma  present  with  lymph  node  involvement  or  distant  metastases.  Even  in  patients  with  localized  disease  who  undergo  resection  with  curative  intent,  the  prognosis  is  poor,  and  no  studies  have  yet  demonstrated  a  clear  benefit  from  adjuvant  therapy.  However,  there  have  been  some  recent  advances  in  the  use  of  chemotherapy  as  palliative  treatment.  In  this  chapter,  the  epidemiology,  diagnosis,  and  treatment  of  small  bowel  cancers,  in  particular  small  bowel  adenocarcinoma,  are  reviewed.