RT Book, Section A1 Ropper, Allan H. A1 Samuels, Martin A. A1 Klein, Joshua P. A1 Prasad, Sashank SR Print(0) ID 1162592925 T1 Fatigue, Asthenia, Anxiety, and Depression T2 Adams and Victor's Principles of Neurology, 11e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071842617 LK accessmedicine.mhmedical.com/content.aspx?aid=1162592925 RD 2024/04/19 AB In this chapter, we consider the clinically related phenomena of fatigue, nervousness, irritability, anxiety, and depression. These complaints form the core of a group of “symptom-based” disorders with normal neurologic findings that are nevertheless a large part of medical practice. Although more abstruse than paralysis, sensory loss, seizures, or aphasia, they are no less important, if for no other reason than their frequency. In an audit of a large neurologic practice, anxiety and depressive reactions were the main diagnosis in 20 percent of patients, second only to the symptom of headache (Digon et al). Similarly, in two primary care clinics in Boston and Houston, fatigue was the prominent complaint over 20 percent of patients. Some of these symptoms represent only slight aberrations of function or a heightening or exaggeration of normal reactions to environmental stress or to diseases; others are integral features of the diseases themselves; and still others represent disturbances of neuropsychiatric function that are components of the diseases described in Chaps. 47, 48 and 49 on psychiatric diseases as viewed through the perspective of neurology.