RT Book, Section A1 MA, Lichtman A1 MS, Shafer A1 RE, Felgar A1 N, Wang SR Print(0) ID 1138038899 T1 BCL-2 and ALK-1 Immunostains T2 Lichtman's Atlas of Hematology 2016 YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071602679 LK accessmedicine.mhmedical.com/content.aspx?aid=1138038899 RD 2024/10/14 AB Graphic Jump LocationView Full Size||Download Slide (.ppt)X.E.001BCL-2 immunostain in follicular lymphoma. These images illustrate the typical staining of (A) neoplastic follicles in follicular lymphoma as compared to (B) benign, reactive germinal centers. Note that in follicular lymphoma neoplastic centrocytes equivalent to neoplastic germinal center cells overexpress the anti-apoptotic protein BCL-2 (arrows), whereas in reactive germinal center, no appreciable staining is noted (arrow), but mantle zone cells surrounding the germinal center (asterisk) are positive. In follicular lymphoma, the overexpression of BCL-2 can be attributed in about 80% to 85% of cases to a translocation involving the immunoglobulin heavy chain locus on chromosome 14q32 and the BCL-2 gene locus on chromosome 18q21, resulting in a constitutive overexpression of this protein.