RT Book, Section
A1 MA, Lichtman
A1 MS, Shafer
A1 RE, Felgar
A1 N, Wang
SR Print(0)
ID 1138038899
T1 BCL-2 and ALK-1 Immunostains
T2 Lichtman's Atlas of Hematology 2016
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071602679
LK accessmedicine.mhmedical.com/content.aspx?aid=1138038899
RD 2024/04/25
AB Graphic  Jump  LocationView  Full  Size||Download  Slide  (.ppt)X.E.001BCL-2  immunostain  in  follicular  lymphoma.  These  images  illustrate  the  typical  staining  of  (A)  neoplastic  follicles  in  follicular  lymphoma  as  compared  to  (B)  benign,  reactive  germinal  centers.  Note  that  in  follicular  lymphoma  neoplastic  centrocytes  equivalent  to  neoplastic  germinal  center  cells  overexpress  the  anti-apoptotic  protein  BCL-2  (arrows),  whereas  in  reactive  germinal  center,  no  appreciable  staining  is  noted  (arrow),  but  mantle  zone  cells  surrounding  the  germinal  center  (asterisk)  are  positive.  In  follicular  lymphoma,  the  overexpression  of  BCL-2  can  be  attributed  in  about  80%  to  85%  of  cases  to  a  translocation  involving  the  immunoglobulin  heavy  chain  locus  on  chromosome  14q32  and  the  BCL-2  gene  locus  on  chromosome  18q21,  resulting  in  a  constitutive  overexpression  of  this  protein.