RT Book, Section
A1 MA, Lichtman
A1 MS, Shafer
A1 RE, Felgar
A1 N, Wang
SR Print(0)
ID 1138037815
T1 Abnormal Erythroid Precursor Cells
T2 Lichtman's Atlas of Hematology 2016
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071602679
LK accessmedicine.mhmedical.com/content.aspx?aid=1138037815
RD 2024/04/23
AB Graphic  Jump  LocationView  Full  Size||Download  Slide  (.ppt)V.G.001Alcohol  poisoning.  Marrow  cells  of  a  patient  with  chronic  and  acute  alcoholism.  Note  dyserythropoiesis.  Small  erythroblasts  with  scant  cytoplasm.  Large  orthochromatic  erythroblast  with  lobulated  nucleus.  Three  large  erythroblasts  (one  proerythroblast  and  two  basophilic  erythroblasts)  with  vacuoles  characteristic  (but  not  specific  for)  of  acute  alcoholism.  The  vacuoles  usually  occur  in  early  erythroid  cells  as  seen  here  and  very  occasionally  in  myeloid  cells.  They  may  be  observed  after  abstinence  for  about  3  to  14  days,  suggesting  the  vacuoles  persist  that  long  despite  cell  division  and  maturation.  The  vacuoles  often  appear  to  overlie  the  nucleus  as  well  as  the  cytoplasm,  but  in  electron  micrographic  studies,  they  form  from  endocytotic  vesicles  and  are  localized  only  to  the  cytoplasm.