RT Book, Section
A1 MA, Lichtman
A1 MS, Shafer
A1 RE, Felgar
A1 N, Wang
SR Print(0)
ID 1138037481
T1 Blood, Marrow, and Pleural Fluid
T2 Lichtman's Atlas of Hematology 2016
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071602679
LK accessmedicine.mhmedical.com/content.aspx?aid=1138037481
RD 2024/04/24
AB Graphic  Jump  LocationView  Full  Size||Download  Slide  (.ppt)III.A.001Anaplasmosis  (Ehrlichosis).  Blood  film  showing  intracellular  Anaplasma  (arrows).  Anaplasmosis  is  caused  by  the  bacterium  Anaplasma  phagocytophilum,  a  genus  assigned  to  the  family  Rickettsiae.  The  organism  was  previously  called  Ehrlichia  phagocytophilum  and  the  disease  Ehrlichosis  before  the  names  were  changed.  Human  Granulocytic  Ehrlichiosis  is  now  called  Human  Granulocytic  Anaplasmosis.  The  bacterium  is  transmitted  to  humans  by  the  bite  of  a  tick.  Headache,  fever,  chills,  malaise,  and  muscle  aches  are  the  most  common  symptoms.  Rash  is  very  uncommon.  These  symptoms  occur  within  1  to  2  weeks  of  a  tick  bite.  Anaplasmosis  can  be  suspected  based  on  the  clinical  presentation,  a  history  of  a  tick  bite  (often  this  is  not  recalled),  a  low  white  blood  cell  count  and  low  platelet  count  (present  in  half  the  cases),  and  elevated  levels  of  liver  enzymes.  Severe  clinical  presentations  may  include  difficulty  breathing,  hemorrhage,  renal  failure  or  neurological  problems.  Anaplasmosis  can  be  a  serious  illness  that  can  be  fatal  if  not  treated  correctly.  The  organism  is  an  obligate  parasite  of  neutrophils  as  shown  in  this  image  and  undergo  their  life  cycle  in  leukocytes  and  platelets.  A  firm  diagnosis  is  made  using  the  polymerase  chain  reaction  or  by  immunostaining.