RT Book, Section A1 Tobias, Adam Z. A2 Tintinalli, Judith E. A2 Stapczynski, J. Stephan A2 Ma, O. John A2 Yealy, Donald M. A2 Meckler, Garth D. A2 Cline, David M. SR Print(0) ID 1121519213 T1 Psychoses T2 Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071794763 LK accessmedicine.mhmedical.com/content.aspx?aid=1121519213 RD 2024/03/28 AB Psychosis has been defined as a "fundamental derangement of the mind characterized by defective or lost contact with reality."1 The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V),2 defines psychotic disorders as those that include abnormalities in one or more of five domains: hallucinations, delusions, disorganized or abnormal motor behavior, disorganized thinking, and negative symptoms. The hallmark of these psychoses, schizophrenia, has a worldwide prevalence of 0.5% to 1%3 and affects approximately 2.4 million adults in the United States.4 Considered one of the leading causes of chronic incapacity, the term schizophrenia, meaning "split mind," was coined by Eugene Bleuler in 1911.5 The economic burden of schizophrenia in the United States in 2002 was estimated at $62.7 billion6 and typically accounts for 1.5% to 3% of the total national healthcare expenditure, with a high incidence of ED utilization.7