RT Book, Section
A1 Nelson, Jessie G.
A1 Hemphill, Robin R.
A2 Tintinalli, Judith E.
A2 Stapczynski, J. Stephan
A2 Ma, O. John
A2 Yealy, Donald M.
A2 Meckler, Garth D.
A2 Cline, David M.
SR Print(0)
ID 1121500709
T1 Clotting Disorders
T2 Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071794763
LK accessmedicine.mhmedical.com/content.aspx?aid=1121500709
RD 2024/04/18
AB Most  patients  who  develop  an  arterial  or  venous  thrombosis  do  so  because  of  local  factors  (e.g.,  a  focal  atherosclerotic  lesion  producing  a  thrombus  in  an  coronary  artery)  or  major  systemic  events  (e.g.,  trauma,  surgery,  or  prolonged  immobilization).  However,  several  inherited  genetic  mutations  predispose  patients  to  venous  thromboembolism  with  some  studies  finding  up  to  50%  of  patients  with  venous  thromboembolism  having  a  thrombophilia  (Table  234-1).1  Importantly,  risk  for  clotting  from  genetic,  acquired,  and  environmental  factors  is  additive  or  even  multiplicative;  a  patient  with  mild  deficiency  may  develop  a  deep  venous  thrombosis  when  started  on  estrogen.2