RT Book, Section
A1 Reid, Marion E.
A1 Lomas-Francis, Christine
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121105695
T1 Erythrocyte Antigens and Antibodies
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK accessmedicine.mhmedical.com/content.aspx?aid=1121105695
RD 2024/04/19
AB SUMMARYBlood  group  antigens  are  structures  on  the  outer  surface  of  human  red  blood  cells  (RBCs)  that  can  be  recognized  by  the  immune  system  of  individuals  who  lack  that  particular  structure.  Identification  of  RBC  antigens  and  antibodies  has  been  the  basis  of  pretransfusion  compatibility  testing  and  the  safe  transfusion  practices  used  today  and  also  can  provide  insights  into  understanding  the  etiology  of  hemolytic  disease  of  the  fetus  and  the  newborn.  Biochemical  and  molecular  studies  have  led  to  definition  of  the  biologic  functions  of  molecules  expressing  blood  group  antigens.  These  molecules  play  a  critical  role  in  susceptibility  to  infection  by  malarial  parasites,  some  viruses,  and  bacteria.  Alteration  of  RBC  antigen  expression  is  associated  with  many  molecular  backgrounds  and  some  play  a  role  in  the  clinical  manifestations  of  certain  diseases.  Erythrocytes,  far  from  being  inert  containers  of  hemoglobin,  are  active  in  a  variety  of  physiologic  processes.