RT Book, Section
A1 Greenberger, Norton J.
A2 Greenberger, Norton J.
A2 Blumberg, Richard S.
A2 Burakoff, Robert
SR Print(0)
ID 1119989810
T1 Approach to the Patient with Jaundice & Abnormal Liver Tests
T2 CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 3e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071837729
LK accessmedicine.mhmedical.com/content.aspx?aid=1119989810
RD 2023/03/23
AB ESSENTIALS  OF  DIAGNOSISJaundice  is  most  often  caused  by  decompensation  of  preexisting  chronic  liver  disease,  alcoholic  hepatitis,  and  gallstone  disease.Careful  history,  physical  examination,  and  routine  laboratory  tests  lead  to  accurate  diagnosis  in  85%  of  patients  with  jaundice.Cirrhosis  can  be  diagnosed  on  the  basis  of  two  physical  findings  (asterixis,  ascites)  and  two  laboratory  findings  (decreased  serum  albumin  [1.6]).Dilated  intrahepatic  bile  ducts  indicate  obstruction  from  extrahepatic  causes  (stone,  structure,  tumor).Absence  of  dilated  ducts  in  jaundiced  patients  with  serum  bilirubin  >10  mg/dL  suggests  intrahepatic  cholestasis.Sepsis,  drugs,  sickle  cell  disease,  and  chronic  hepatitis  are  the  most  common  causes  of  intrahepatic  cholestasis.