RT Book, Section
A1 Greenberger, Norton J.
A2 Greenberger, Norton J.
A2 Blumberg, Richard S.
A2 Burakoff, Robert
SR Print(0)
ID 1119986965
T1 Eosinophilic Esophagitis
T2 CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 3e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071837729
LK accessmedicine.mhmedical.com/content.aspx?aid=1119986965
RD 2023/03/24
AB ESSENTIALS  OF  DIAGNOSISIn  adults,  a  major  symptom  is  recurrent  dysphagia,  often  with  food  impaction;  mean  duration  of  symptoms  before  treatment  is  4–6  years.Esophageal  biopsy  shows  dense  eosinophilic  infiltration  (≥15  eosinophils  per  high-power  field  [HPF]).Full  diagnostic  criteria  are  (1)  clinical  symptoms  of  esophageal  dysfunction;  (2)  increased  eosinophils  in  esophageal  mucosal  biopsies;  (3)  secondary  causes  of  esophageal  eosinophilia  have  been  excluded;  (4)  lack  of  sustained  response  to  high-dose  proton  pump  inhibition  treatment  or  normal  pH  monitoring  of  the  distal  esophagus;  (5)  response  to  treatment  (elimination  diet,  topical  glucocorticoids)  supports  the  diagnosis.