RT Book, Section
A1 Dai, Yun
A1 Bose, Prithviraj
A1 Grant, Steven
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121089641
T1 Cell-Cycle Regulation and Hematologic Disorders
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK accessmedicine.mhmedical.com/content.aspx?aid=1121089641
RD 2024/04/24
AB SUMMARYComplex  feedback  pathways  regulate  the  passage  of  cells  through  the  G1,  S,  G2,  and  M  phases  of  the  growth  cycle.  Two  key  checkpoints  control  the  commitment  of  cells  to  replicate  DNA  synthesis  and  to  mitosis.  Many  oncogenes  and  defective  tumor-suppressor  genes  promote  malignant  change  by  stimulating  cell-cycle  entry,  or  disrupting  the  checkpoint  response  to  DNA  damage.  Advances  in  the  understanding  of  genetic  and  epigenetic  mechanisms  of  gene  regulation  provide  the  basis  for  novel  therapeutic  approaches.  This  chapter  presents  the  pathways  and  the  genetic  and  epigenetic  alterations  that  regulate  cell  replication,  and  highlights  the  various  oncogenes  and  tumor-suppressor  genes  that  are  involved  in  hematologic  malignancies.