TY  - CHAP
M1  - Book, Section
TI  - Sepsis, Multiple Organ Dysfunction Syndrome, and Chronic Critical Illness
A1  - Gordon, Emily K. B.
A1  - Deutschman, Clifford S.
A2  - Grippi, Michael A.
A2  - Elias, Jack A.
A2  - Fishman, Jay A.
A2  - Kotloff, Robert M.
A2  - Pack, Allan I.
A2  - Senior, Robert M.
A2  - Siegel, Mark D.
PY  - 2015
T2  - Fishman's Pulmonary Diseases and Disorders, 5e
AB  - The  past  four  decades  have  added  greatly  to  our  recognition  that  sepsis,  originally  defined  as  a  syndrome  induced  by  actively  dividing  microorganisms  in  the  circulation,  is,  in  fact,  a  complex  and  diverse  disorder.  The  term  has  now  come  to  encompass  a  constellation  of  abnormalities  that  reflect  disordered  or  dysregulated  inflammation.  As  such,  sepsis  may  be  initiated  by  infection;  however,  it  may  also  occur  in  the  absence  of  microbial  invasion,  for  example,  in  response  to  extensive  trauma,  uninfected  pancreatitis,  ruptured  aortic  aneurysm,  or  some  distinctly  unusual  entities,  such  as  amniotic  fluid  embolism.  All  such  patients  may  develop  multiple  organ  dysfunction  syndrome  (MODS)  and  a  newly  recognized  state  currently  called  “chronic  critical  illness  (CCI).”  What  is  now  apparent  is  that  our  ability  to  manage  shock  and  to  support  organ  function  has  unmasked  a  common  ­family  of  disorders  that  have  a  high  mortality  and  significant  morbidity.  Familiarity  with  sepsis  is  essential  for  all  medical  practitioners.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1122371285
ER  -