TY - CHAP M1 - Book, Section TI - Bleeding Disorders A1 - Thomas, Karl A2 - Hall, Jesse B. A2 - Schmidt, Gregory A. A2 - Kress, John P. PY - 2015 T2 - Principles of Critical Care, 4e AB - Bleeding disorders and hemorrhagic complications are common in ICU patients.Bleeding disorders may be divided into thrombocytopenias, soluble coagulation factor deficiencies, and combined disorders.Initial management approaches to thrombocytopenias vary considerably and create the necessity for early recognition of distinct disorders including heparin-induced thrombocytopenia, thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, and other common thrombocytopenias.Disorders of soluble coagulation factors are revealed by abnormal results in the prothrombin time, activated partial thromboplastin time, and other tests including thromboelastography.Factor deficiencies, factor inhibitors, von Willebrand disease, and other complex coagulopathies including disseminated intravascular coagulation, HELLP syndrome, massive transfusion, and anticoagulant-related syndromes have specific therapies to reduce the rate and risk of bleeding.There are specific indications and appropriate applications for platelet transfusion, cryoprecipitate, fresh frozen plasma, concentrated and activated factors, as well as other medications, including inhibitors of fibrinolysis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1107722691 ER -