TY - CHAP M1 - Book, Section TI - Hypertensive Vascular Disease A1 - Kotchen, Theodore A. A2 - Kasper, Dennis A2 - Fauci, Anthony A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry A2 - Loscalzo, Joseph PY - 2014 T2 - Harrison's Principles of Internal Medicine, 19e AB - Hypertension is one of the leading causes of the global burden of disease. Approximately 7.6 million deaths (13–15% of the total) and 92 million disability-adjusted life years worldwide were attributable to high blood pressure in 2001. Hypertension doubles the risk of cardiovascular diseases, including coronary heart disease (CHD), congestive heart failure (CHF), ischemic and hemorrhagic stroke, renal failure, and peripheral arterial disease. It often is associated with additional cardiovascular disease risk factors, and the risk of cardiovascular disease increases with the total burden of risk factors. Although antihypertensive therapy reduces the risks of cardiovascular and renal disease, large segments of the hypertensive population are either untreated or inadequately treated. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2021/01/21 UR - accessmedicine.mhmedical.com/content.aspx?aid=1120806951 ER -