TY  - CHAP
M1  - Book, Section
TI  - Leukocyte Accumulation in Pulmonary Disease
A1  - Lukacs, Nicholas W.
A1  - Ward, Peter A.
A2  - Grippi, Michael A.
A2  - Elias, Jack A.
A2  - Fishman, Jay A.
A2  - Kotloff, Robert M.
A2  - Pack, Allan I.
A2  - Senior, Robert M.
A2  - Siegel, Mark D.
PY  - 2015
T2  - Fishman's Pulmonary Diseases and Disorders, 5e
AB  - Mediators  produced  during  inflammatory/immune  responses  dictate  the  severity  and  intensity  of  pulmonary  disease.  The  profile  of  inflammatory  leukocyte  populations  accumulating  in  inflamed  tissues  is  initiated  by  cytokine-induced  expression  of  adhesion  molecules  on  the  vascular  endothelium.  Endothelial  adhesion  molecules  include  intracellular  adhesion  molecule-1  (ICAM-1),  vascular  cell  adhesion  molecule-1  (VCAM-1),  as  well  as  E-  and  P-selectins  that  initiate,  and  in  some  cases,  mediate  the  migration  of  leukocytes  into  tissues.  Subsequently,  leukocyte  adherence  to  the  endothelium  is  followed  by  leukocyte  migration  into  the  inflamed  tissue,  directed  by  chemotactic  molecules  at  the  site  of  the  inflammatory/immune  response.  Upregulation  of  these  early  response  mediators  is  crucial  for  the  initiation  of  early  events  that  regulate  the  inciting  agent,  whether  it  is  infectious  or  noninfectious  in  nature.  However,  the  continuous  over-production  of  these  mediators  can  lead  to  destructive,  pathologic  consequences  due  to  the  continued  recruitment  and  activation  of  disease-specific  leukocyte  populations.  In  human  lung,  inflammation-induced  damage  can  be  observed  in  numerous  inflammatory  diseases,  including  both  acute  and  chronic  disease  settings.  In  this  chapter,  we  will  examine  the  mediators  that  promote  inflammatory  diseases  in  lung  and  outline  how  specific  leukocyte  populations  can  contribute  to  pulmonary  pathology.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1122356063
ER  -