TY - CHAP M1 - Book, Section TI - Sickle Cell Disease A1 - Bunn, H. Franklin A2 - Bunn, H. Franklin A2 - Aster, Jon C. PY - 2011 T2 - Pathophysiology of Blood Disorders AB - LEARNING OBJECTIVESAfter studying this chapter you should understand:The inheritance of sickle cell disease and the difference between hemoglobin SS homozygotes, hemoglobin AS heterozygotes, and compound heterozygotes (hemoglobin SC and hemoglobin S/β-thalassemia).The molecular basis for polymerization of deoxyhemoglobin S.The process of sickle vaso-occlusion.The clinical manifestations of sickle cell disease: acute pain crises and progressive organ damage.The treatment of sickle cell disease: supportive care and prevention of sickling. SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/10/03 UR - accessmedicine.mhmedical.com/content.aspx?aid=1104131137 ER -