TY - CHAP M1 - Book, Section TI - Hypertrophic Cardiomyopathy A1 - Teekakirikul, Polakit A1 - Seidman, Christine E. A1 - Ho, Carolyn Y. A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. PY - 2014 T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:Hypertrophic cardiomyopathy (HCM) is an inherited disorder of cardiac muscle characterized by left ventricular hypertrophy (LVH) in the absence of other cardiovascular or systemic conditions (eg, valvular heart diseases or long-standing hypertension).The histopathologic hallmarks include myocyte hypertrophy, myocardial disarray, and fibrosis.The prevalence of HCM is 1:500 in the general population, with at least 60% caused by mutation in one of the genes encoding different components of the sarcomere protein (see Molecular Genetics section). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1102699478 ER -