TY  - CHAP
M1  - Book, Section
TI  - Dyslipidemia
A1  - Kiss, Daniel
A1  - Rader, Daniel J.
A2  - Murray, Michael F.
A2  - Babyatsky, Mark W.
A2  - Giovanni, Monica A.
A2  - Alkuraya, Fowzan S.
A2  - Stewart, Douglas R.
PY  - 2014
T2  - Clinical Genomics: Practical Applications in Adult Patient Care
AB  - Disease  summary:Hyperlipidemia  describes  the  phenotype  of  elevated  blood  lipids,  predisposing  a  patient  to  atherosclerotic  vascular  disease.  The  overall  heritability  of  blood  lipids  is  often  due  to  the  interaction  of  a  variety  of  alleles.Classic  Mendelian  monogenic  lipoprotein  disorders,  while  rare,  have  provided  profound  insight  into  lipoprotein  metabolism  and  atherosclerotic  vascular  disease.Originally  characterized  by  Fredrickson  and  Levy  by  the  type  of  lipoprotein  that  accumulated  in  the  circulation,  the  modern  approach  to  classic  Mendelian  monogenic  disorders  emphasizes  the  molecular  basis  of  the  disease  and  the  defect  in  cholesterol  metabolism.Within  the  population,  blood  lipid  variation  is  typically  the  consequence  of  variation  at  multiple  loci,  in  addition  to  significant  effect  from  the  environment.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1102698842
ER  -