TY - CHAP M1 - Book, Section TI - Common Cytochrome P450 Polymorphisms and Pharmacogenetics A1 - Zanger, Ulrich M. A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. PY - 2014 T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:In this chapter, relatively common (>1% frequency) and ethically diverse genetic polymorphisms of drug-metabolizing cytochrome P450s (CYPs) will be reviewed. In general, these variantsAffect pharmacokinetics and response to drugs which are substrates of these enzymesAre not usually associated with drug-independent clinical phenotypesHave pharmacokinetic phenotypes categorized as poor, intermediate, normal (extensive), and ultrarapid metabolizer (UM)Have clinical phenotypes which depend on the particular pharmacologic situation (drug, prodrug, therapeutic index, etc) SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1102698429 ER -