TY  - CHAP
M1  - Book, Section
TI  - The Skin and Subcutaneous Tissue
A1  - Khan, Sajid A.
A1  - Bank, Jonathan
A1  - Song, David H.
A1  - Choi, Eugene A.
A2  - Brunicardi, F. Charles
A2  - Andersen, Dana K.
A2  - Billiar, Timothy R.
A2  - Dunn, David L.
A2  - Hunter, John G.
A2  - Matthews, Jeffrey B.
A2  - Pollock, Raphael E.
PY  - 2015
T2  - Schwartz's Principles of Surgery, 10e
AB  - The  epidermis  consists  of  continually  regenerating  stratified  epithelium,  and  90%  of  cells  are  comprised  of  ectodermally  derived  keratinocytes.Dermal  fibers  are  predominantly  made  of  type  I  and  III  collagen  in  a  4:1  ratio.  They  are  responsible  for  the  mechanical  resistance  of  skin.Staphylococcus  aureus  is  the  most  common  isolate  of  all  skin  infections.  Impetigo,  cellulitis,  erysipelas,  folliculitis,  furuncles,  and  simple  abscesses  are  examples  of  uncomplicated  infections,  whereas  deep-tissue  infections,  extensive  cellulitis,  necrotizing  fasciitis,  and  myonecrosis  are  examples  of  complicated  infections.Hemangiomas  arise  from  benign  proliferation  of  endothelial  cells  surrounding  blood-filled  cavities.  They  most  commonly  present  after  birth,  rapidly  grow  during  the  first  year  of  life,  and  gradually  involute  in  most  cases.Basal  cell  carcinoma  represents  the  most  common  tumor  diagnosed  in  the  United  States,  and  the  nodular  variant  is  the  most  common  subtype.Squamous  cell  carcinoma  is  the  second  most  common  skin  cancer,  and  primary  treatment  modalities  are  surgical  excision  and  Moh’s  microsurgery.  Cautery  and  ablation,  cryotherapy,  drug  therapy,  and  radiation  therapy  are  alternative  treatments.Tumor  thickness,  ulceration,  and  mitotic  rate  are  the  most  important  prognostic  indicators  of  survival  in  melanoma.  If  a  sentinel  node  contains  metastatic  cancer,  prognosis  is  determined  by  the  number  of  positive  nodes,  the  primary  tumor  thickness,  mitotic  rate  and  ulceration,  and  the  age  of  the  patient.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1117743615
ER  -