TY - CHAP M1 - Book, Section TI - Chapter 15. Rheumatoid Arthritis A1 - O'Dell, James R. A1 - Imboden, John B. A1 - Miller, Lester D. A2 - Imboden, John B. A2 - Hellmann, David B. A2 - Stone, John H. PY - 2013 T2 - CURRENT Diagnosis & Treatment: Rheumatology, 3e AB - Rheumatoid arthritis (RA) is a chronic, systemic disease that primarily targets the synovium, leading to synovial inflammation and proliferation, loss of articular cartilage, and erosion of juxtarticular bone. The natural history of the disease is one of progressive joint damage and deformity and, in a sizeable minority, the development of extra-articular manifestations. Fortunately, current therapeutic strategies, particularly if the disease is diagnosed and treated early, result in substantial clinical benefit for most patients. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/11/06 UR - accessmedicine.mhmedical.com/content.aspx?aid=57271714 ER -