TY - CHAP M1 - Book, Section TI - Chapter 45. Oxygen Toxicity A1 - Lodato, Robert F. A2 - Tobin, Martin J. PY - 2013 T2 - Principles and Practice of Mechanical Ventilation, 3e AB - The importance of the physiology and toxicology of oxygen (O2) breathing have increased in recent years. The past 25 years have witnessed a remarkable upsurge of knowledge and interest in “oxidative stress” throughout all of biology. The use of O2 continues to grow, from critically ill to ambulatory patients and even to recreational use at “oxygen bars.”1 Recent advances in patient care have refocused attention on the optimum use of O2. For example, currently, strategies to protect the lung from mechanical injury during mechanical ventilation emphasize the use of lower tidal volumes. But such strategies may impair gas exchange, resulting in higher requirements for inspired O2 fraction (FIO2).2 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=57075902 ER -