TY - CHAP M1 - Book, Section TI - Chapter 32. Mechanical Ventilation in Neuromuscular Disease A1 - Baydur, Ahmet A2 - Tobin, Martin J. PY - 2013 T2 - Principles and Practice of Mechanical Ventilation, 3e AB - The earliest application of assisted ventilation in patients with neuromuscular disease was with the iron lung during the poliomyelitis epidemic in the 1940s and 1950s, which enabled patients with severe respiratory insufficiency to recover, become ventilator-free, and go on to lead productive lives.1 In most cases, the device was used for a few weeks to up to 2 years, with eventual recovery of ventilatory function. Many polio patients with disability continue to reside in iron lungs in the community after several decades.2 Others have converted to tracheostomy-assisted positive-pressure ventilation, achieving mobility and the ability to clear airway secretions. With appropriate weaning techniques, some have switched to noninvasive positive-pressure ventilation (NIPPV).3 NIPPV is now preferred to support most patients with chronic neuromuscular disorders and is used increasingly to support patients with acute ventilatory insufficiency, such as with Guillain-Barré syndrome and myasthenia gravis. Table 32-1 lists neuromuscular conditions associated with respiratory impairment and failure. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=57071206 ER -