TY - CHAP M1 - Book, Section TI - Chapter 135. Analgesia, Paralytics, and Sedation A1 - Margolias, Gary A1 - Harris, Robert S. A2 - McKean, Sylvia C. A2 - Ross, John J. A2 - Dressler, Daniel D. A2 - Brotman, Daniel J. A2 - Ginsberg, Jeffrey S. PY - 2012 T2 - Principles and Practice of Hospital Medicine AB - What are the clinical and pharmacologic effects of single agent versus multiple agent sedative and analgesic administration?What is the best way to dose sedative, analgesic, and paralytic agents in the intensive care unit (ICU)?How do the pharmacokinetics and dosing of sedative, analgesic, and paralytic agents change with duration of infusion?What is the proper sequence to initiate sedatives, analgesics, and/or paralytics, and how does dosing refinement affect time to weaning and other predictors of favorable outcome?How should a hospitalist select individual sedative, analgesic, or paralytic agents in critically ill patients?When should a hospitalist decide to paralyze a ventilated patient? SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=56203728 ER -