TY - CHAP M1 - Book, Section TI - Chapter 248. Mechanisms of Wound Repair, Wound Healing, and Wound Dressing A1 - Falanga, Vincent A1 - Iwamoto, Satori A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintWound Repair at a GlanceAcute and chronic wounds are different but overlap.In acute wounds, there is an orderly progression from injury to coagulation, inflammation, proliferation, cell migration, and tissue modeling.In the initial phases, a wide range of growth factors, including platelet-derived growth factor and transforming growth factor-β1, play an important role. In the proliferation/migration and modeling phases, tissue matrix metalloproteinases (MMPs), integrins, basic fibroblast growth factor, and endothelial growth factor are critical. MMP-1, MMP-9, and MMP-10 are essential for remodeling.Moist wounds heal faster, and a variety of wound dressings are now available to fit this requirement. They include transparent films, hydrocolloids, foams, alginates, gels, and collagen-based products.Chronic wounds are different from acute wounds in that the one-way relationship between the different phases is lost. Chronic wounds are the complex result of ischemia, pressure, and infection; healing is highly dependent on these factors.Wound healing of skin grafts is also different, as it is completely dependent on revascularization, be it true neovascularization or inosculation. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56106991 ER -