TY - CHAP M1 - Book, Section TI - Chapter 175. General Considerations of Bacterial Diseases A1 - Craft, Noah A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintBacterial Skin Diseases at a GlanceBacteria cause disease by direct invasion of tissues, by secreting toxins, and by causing immunologic consequences that result in disease.The innate immune system is critical in the initial defense against bacterial entry into the skin.The virulence and pathogenicity of bacteria is related to their ability to avoid activating the innate immune system or resisting killing within immune effector cells.Immunosuppression, especially neutropenia, puts the host at high risk for bacterial infections; some infections are rare except in the immunocompromised host.Consideration of host factors and pathogen virulence factors are critical to choose a safe and effective therapy against bacterial infections.There are many noninfectious conditions that can mimic the clinical presentations of bacterial infections. Consider the noninfectious differential diagnoses carefully.The use of up-to-date computer based resources for antibiotic resistance trends and best-practice guidelines is important when choosing empiric antimicrobial therapy. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/11/01 UR - accessmedicine.mhmedical.com/content.aspx?aid=56081413 ER -