TY  - CHAP
M1  - Book, Section
TI  - Chapter 167. Kawasaki Disease
A1  - Rowley, Anne H.
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
PY  - 2012
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintKawasaki  Disease  at  a  GlanceMost  common  cause  of  acquired  heart  disease  in  children  in  developed  nations.Highest  incidence  in  Asian  children;  1  in  100  Japanese  children  develops  Kawasaki  disease  (KD)  by  age  5  years.KD  is  a  multisystem  inflammatory  process  of  unknown  but  suspected  infectious  etiology.KD  affects  all  blood  vessels  in  the  body,  particularly  medium-sized  arteries  such  as  the  coronary  arteries.Major  symptoms  are  prolonged  high  fever,  conjunctival  injection,  oral  mucosal  changes  such  as  red  lips  and  pharynx  and  strawberry  tongue,  redness  and  swelling  of  the  hands  and  feet,  erythematous  polymorphic  rash,  and  cervical  lymphadenopathy.Inflammation  in  the  coronary  arteries  can  lead  to  aneurysms  with  subsequent  myocardial  infarction,  aneurysm  rupture,  and  sudden  death.Treatment  with  intravenous  immunoglobulin  (IVIG)  and  aspirin,  when  given  in  the  first  10  days  of  fever,  reduces  the  prevalence  of  coronary  artery  abnormalities  from  25%  in  those  treated  with  aspirin  alone,  to  5%  in  those  who  receive  IVIG  with  aspirin.Long-term  complications  are  confined  to  the  heart  and  vascular  tree,  primarily  thrombosis  and  stenosis  of  the  major  coronary  arteries  with  myocardial  ischemia.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/23
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56079418
ER  -