TY - CHAP M1 - Book, Section TI - Chapter 139. Hereditary Disorders of Genome Instability and DNA Repair A1 - RĂ¼nger, Thomas M. A1 - DiGiovanna, John J. A1 - Kraemer, Kenneth H. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintHereditary Disorders of Genome Instability and DNA Repair at a GlanceGenome instability characterizes a large group of inherited disorders with prominent cutaneous abnormalities; many have an increased cancer risk.Genome instability is caused by impaired repair and/or maintenance of DNA.Xeroderma pigmentosum is a prototype with impaired repair of environmentally induced DNA damage and a greatly increased frequency of sunlight-induced cancer.Although these disorders are rare, heterozygotic carriers of affected genes, which may comprise several percent of the general population, may carry an increased cancer risk as well. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56069453 ER -