TY - CHAP M1 - Book, Section TI - Chapter 117. Keratoacanthoma A1 - Cerroni, Lorenzo A1 - Kerl, Helmut A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintKeratoacanthoma at a GlanceA common, rapidly growing epithelial tumor with histopathologic features similar to squamous cell carcinoma and a tendency to spontaneous regression.Considered by some a variant of squamous cell carcinoma because of potential of metastases and local tissue destruction if untreated. Considered by others a pseudocancer, but this issue is unresolved.Clinically, keratoacanthoma is mostly a rapidly growing, hyperkeratotic solitary tumor. Multiple keratoacanthomas occur.Predilection for sun-exposed areas.May be associated with Muir–Torre syndrome.Pathology reveals a central keratotic plug surrounded by an epithelial proliferation with atypical keratinocytes and mitoses; neurotropism may be observed. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=56059933 ER -