TY  - CHAP
M1  - Book, Section
TI  - Chapter 69. Acquired Perforating Disorders
A1  - Minocha, Julia S.
A1  - Schlosser, Bethanee J.
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
PY  - 2012
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintAcquired  Perforating  Disorders  at  a  GlanceAcquired  perforating  disorders  represent  a  group  of  separately  identified  cutaneous  disorders  that  occur  most  often  in  the  setting  of  chronic  renal  disease  or  diabetes  mellitus.The  previously  recognized  Kyrle's  disease  (KD),  acquired  elastosis  perforans  serpiginosa  (AEPS),  acquired  reactive  perforating  collagenosis  (ARPC),  and  perforating  folliculitis  (PF)  are  now  classified  under  the  umbrella  term  of  acquired  perforating  dermatosis.Lesions  present  as  umbilicated  papules  and/or  nodules  with  a  central  keratotic  plug  or  crust  distributed  preferentially  on  extensor  surfaces  of  the  extremities.Histopathological  examination  of  lesional  skin  demonstrates  invagination  of  the  epidermis  with  extrusion  of  dermal  material  (collagen,  elastin,  and/or  fibrin)  through  the  cup-shaped  epidermal  depression.Treatment  is  challenging  with  no  universally  effective  therapy,  and  patients  often  exhibit  a  chronic  course.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56041261
ER  -