TY - CHAP M1 - Book, Section TI - Chapter 60. Epidermolysis Bullosa Acquisita A1 - Woodley, David T. A1 - Chen, Mei A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintEpidermolysis Bullosa Acquisita at a GlanceRare, autoimmune subepidermal bullous disease due to immunoglobulin (Ig) G autoantibodies to type VII collagen.Etiology is unknown.Skin fragility, subepidermal blisters, residual scarring, and milia formation. Common sites are trauma-prone areas such as hands, feet, elbows, knees, sacrum, nails, and mouth.Related features may include an underlying systemic disease such as inflammatory bowel disease. May have erosions of the mucosa and esophageal stenosis.Pathology shows subepidermal bulla, fibrosis, milia formation, and positive direct immunofluorescence for IgG deposits at the dermal–epidermal junction.Treatment options are limited and often difficult. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56038543 ER -