TY - CHAP M1 - Book, Section TI - Chapter 52. Porokeratosis A1 - O'Regan, Grainne M. A1 - Alan D., Irvine A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintPorokeratosis at a GlanceA chronic progressive disorder of keratinization, characterized clinically by hyperkeratotic papules or plaques surrounded by a thread-like elevated border that expands centrifugally.At least six clinical variants of porokeratosis have been described.The classic form, porokeratosis of Mibelli, presents in infancy or childhood as asymptomatic small brown to skin-colored annular papules with a characteristic raised border.Disseminated superficial actinic porokeratosis is the most common type, with multiple papules distributed symmetrically on sun-exposed areas.Linear porokeratosis presents at birth or in childhood with lesions distributed along Blaschko's lines.Punctate porokeratosis appears during or after adolescence as 1- to 2-mm papules on the palms or soles.In all variants, a thin column of parakeratotic cells (cornoid lamella) corresponds to the hyperkeratotic border and extends throughout the stratum corneum in histologic sections.A genetically heterogeneous disorder; the majority of forms may be inherited as autosomal dominant traits.Malignant epithelial neoplasms are reported in all subtypes except the punctate variety. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=56036818 ER -