TY - CHAP M1 - Book, Section TI - Chapter 48. Irritant Contact Dermatitis A1 - Amado, Antoine A1 - Sood, Apra A1 - Taylor, James S. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintIrritant Contact Dermatitis at a GlanceIrritant contact dermatitis (ICD) is a nonimmunologic inflammation of the skin caused by contact with a chemical, physical, or biologic agent.Up to 80% percent of contact dermatitis is irritant and is commonly related to occupation.The most important exogenous factor for ICD is the inherent toxicity of the chemical for human skin.Endogenous factors, such as skin barrier function and preexisting dermatitis, play an important role in the pathogenesis of ICD.Atopic dermatitis is a major risk factor for irritant hand dermatitis because of impaired barrier function and a lower threshold for skin irritation.Patch testing should be performed in cases with suspected chronic irritant dermatitis to exclude an allergic contact dermatitis.Identification and avoidance of the potential irritant is the mainstay of treatment. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56034835 ER -