TY - CHAP M1 - Book, Section TI - Chapter 45. Epidermal Stem Cells A1 - Morris, Rebecca J. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintEpidermal Stem Cells at a GlanceThe epidermis is a continually renewing tissue the function of which is maintained by a hierarchy of stem cells, transit amplifying cells, and terminally differentiating cells.In the proliferative hierarchy, stem cells have the highest proliferative potential.Epidermal stem cells may be identified by their functional characteristics, by distinctive cell cycle patterns, or by characteristic proteins.Epidermal stem cells usually exist in characteristic proliferative units with little lateral migration.The regulation of epidermal stem cells comprises complex pathways many of which are shared by embryonic, morphogenetic, and homeostatic processes.Epidermal diseases are associated with or may arise from proliferative dysfunction in the stem cell or transit amplifying cell compartments.Epidermal stem cells are attractive targets for cell and gene therapies. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=56034143 ER -