TY - CHAP M1 - Book, Section TI - Chapter 19. Psoriatic Arthritis A1 - Gladman, Dafna D. A1 - Chandran, Vinod A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintPsoriatic Arthritis at a GlancePsoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis and seronegative for rheumatoid factor.Genetic and environmental factors underlie susceptibility to PsA and immune-mediated inflammation leads to inflammation in musculoskeletal structures.Clinical features of PsA include peripheral and axial arthritis, enthesitis, dactylitis, and tenosynovitis.Extra-articular involvement in addition to skin and nail involvement may include conjunctivitis, uveitis, and inflammatory bowel disease.Investigations may reveal elevated acute phase reactants, although conventional tests such as erythrocyte sedimentation rate and C-reactive protein are normal in up to 50% of patients.Radiographs may reveal soft-tissue swelling, periostitis, erosions, pencil-in-cup change, ankylosis, sacroiliitis, or syndesmophytes.Pharmacotherapy is the mainstay of treatment, and antitumor necrosis factor agents are safe, efficacious, and effective. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56026285 ER -