TY - CHAP M1 - Book, Section TI - Chapter 49. Sickle Cell Nephropathy A1 - Scheinman, Jon I. A2 - Lerma, Edgar V. A2 - Berns, Jeffrey S. A2 - Nissenson, Allen R. PY - 2009 T2 - CURRENT Diagnosis & Treatment: Nephrology & Hypertension AB - The major clinical consequences of sickle cell disease (SCD) are crises from vascular obstruction by sickled cells and anemia because of red blood cell (RBC) destruction. The obstruction can cause hematuria and renal papillary necrosis (RPN) with a defect in tubular function, especially in urinary concentration. The chronic consequences include sickle cell glomerulopathy, more indirectly related to sickling, and a specific form of renal malignancy. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=6339843 ER -