TY - CHAP M1 - Book, Section TI - Chapter 37. Chronic Tubulointerstitial Nephritis A1 - Lerma, Edgar V. A2 - Lerma, Edgar V. A2 - Berns, Jeffrey S. A2 - Nissenson, Allen R. PY - 2009 T2 - CURRENT Diagnosis & Treatment: Nephrology & Hypertension AB - Chronic interstitial nephritis (CIN) is by definition tubulointerstitial nephritis that has failed to resolve on its own or has been resistant to whatever treatment was rendered after several months or years. However, it can also arise de novo as a consequence of chronic, low-grade, or injurious exposures of the tubulointerstitium to the culprit agent, ie, medication, physical factor, infectious agents, etc. Such exposures may be intermittent or persistent. Histopathologically, it is characterized by the presence of interstitial chronic inflammation, interstitial fibrosis, and tubular atrophy (Figure 37–1). SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=6337416 ER -